1. Package leaflet: Information for the user. AVONEX 30 micrograms/ ml solution for Injection. (Interferon beta-1a). Pre-filled syringe. Read all of this leaflet. Package leaflet: Information for the user. AVONEX 30 micrograms/ml solution for injection in pre-filled pen. (Interferon beta-1a). Pre-filled pen. Read all of this. Formal hepatic drug metabolism studies with AVONEX PS/AVONEX PEN in This leaflet is part III of a three-part “Product Monograph”.
|Genre:||Health and Food|
|Published (Last):||13 January 2016|
|PDF File Size:||15.74 Mb|
|ePub File Size:||7.86 Mb|
|Price:||Free* [*Free Regsitration Required]|
Interferon beta-1a should be used cautiously in patients with a history of cardiac disease including angina, cardiac arrhythmias, heart failure, or myocardial infarction. Discontinue riluzole if clinical signs of liver dysfunction are present. Press the needle onto the glass syringe tip. It may be possible for your doctor to prescribe you a shorter and thinner needle depending on your body type.
Interferon beta-1a is classified as FDA pregnancy risk category C. Cobicistat; Elvitegravir; Emtricitabine; Tenofovir Alafenamide: Sometimes they are serious, most of the time they are not.
Concomitant use of ocrelizumab with interferon beta may increase the risk of insfrt. These pacakge effects are very rare. Patients should be monitored for signs of these disorders.
Patients should be advised to avoid drinking alcohol to reduce the chance of injury to the liver during interferon beta treatment. Interferon beta inhibits the expression of pro-inflammatory cytokines including INF-G, which is believed to be a major factor responsible for triggering the autoimmune reaction leading to multiple sclerosis.
Many studies demonstrate that nevirapine is more hepatotoxic than efavirenz. Monitor hepatic function during interferon beta treatment.
Major The concomitant use of interferons and nevirapine should be done with caution as both can cause hepatotoxicity. The most common side effect is to feel ‘flu-like’ symptoms, e.
As compared with data from patients who got late treatment, patients who received interferon beta-1a initially had lower expanded disability status scale progression, relapse rate, and T2 disease burden up to 8 years later; the benefit was greater with the higher interferon beta-1a dose. There is no information on the use of this medicine in those below 12 years of age. After removal from refrigerator, do innsert store product above 25 degrees C. Visually inspect parenteral products for particulate matter and discoloration prior to administration whenever solution and container permit.
Do not be alarmed by the following lists of side effects. Monitoring of liver function tests is recommended at regular intervals jnsert, 3, and 6 months recommended for Rebif following initiation of therapy and then periodically thereafter in the absence of clinical symptoms.
Moderate Monitor for signs and symptoms of hepatic injury during coadministration of riluzole and interferon beta. Recipient’s Email Separate multiple email address with a comma Please enter valid email address Recipient’s email is required. Do not use heat sources heater or hot water to warm it. If it has expired or is damaged or looks differently than it should, return it to your pharmacist for disposal. Subcutaneous administration of the product is appropriate. Refer to the Patient Medication Guide for detailed instructions for preparing and giving a dose.
With help from another person, may rotate between thighs and upper arms.
Avonex (interferon beta-1a) dose, indications, adverse effects, interactions from
Doravirine; Lamivudine; Tenofovir disoproxil fumarate: Interferons and anti-retroviral nucleoside reverse transcriptase inhibitors NRTIs can both cause hepatotoxicity. Discontinue therapy if clinical symptoms and laboratory parameters consistent with thrombotic microangiopathy develop, and manage as appropriate. If any of the following happen, tell your doctor immediately, or go to Accident and Emergency at your nearest hospital:.
Based on effective donor screening and product manufacturing processes, albumin carries an extremely remote risk of transmission of viral infections. The cause of MS is not yet known.
Avonex CMI | Mobile
You will hear a click if the injection is given the right way. Administration of Avonex pre-filled autoinjector: The indicated dose is based on data suggesting that early initiation of pcakage beta-1a therapy delays the onset of clinically definite MS in high-risk patients who have recently experienced a demyelinating event but do not yet have clinical MS. Your doctor will recommend an injection site suitable for you.
Store at 2—8 degrees C 36—46 degrees F. Inserh your doctor or pharmacist if you notice anything that is making you feel unwell. If your doctor tells you to stop using AVONEX or the expiry date has passed, ask your pharmacist what to do with any medicine that is left over.
It is important not to miss injections as this can affect the success of your treatment. If you forget packagw use it If it is less than 2 days before your next injection, skip the dose you missed and have your next injection when you are meant to. Do not give on two consecutive days. Tell your doctor if you are breastfeeding avonxe plan to breastfeed. Therefore, do not use different interferon beta-1a products in a single treatment regimen.
Data from a large, multicenter trial of pregnant patients with MS suggest that patients have a decrease in the number and severity of MS relapses during pregnancy, despite discontinuation or lack of receipt of disease-modifying medications.
Self-injection needs to be taught and practised. If you are not sure whether you should use this aavonex, talk to your doctor or pharmacist. Patients may self-inject only if their physician determines that it is appropriate, and with medical follow-up, and after proper training in intramuscular injection technique.
Specific guidelines for dosage adjustments in renal impairment are not available; it appears that no dosage adjustments are needed. The drug should not be used with interferons, which are associated with a potential for serious ophthalmic effects e. Hold Pen at 90 degree angle to the injection site.
Pinch the skin, and insert the needle at packzge 90 degree angle. Push the syringe down into the device until both ends snap into place. Instruct patients to contact their health care provider if a skin reaction occurs that does not resolve in a few days.